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Soft tissue vascular tumors. A flow cytometric DNA analysis
M Fukunaga1, T Shimoda, T Nikaido
1Department of Pathology, Jikei University School of Medicine, Tokyo, Japan.
Cancer
|April 1, 1993
Summary
DNA flow cytometry has limited value in predicting the behavior of soft tissue vascular tumors. While benign tumors were diploid, DNA content did not correlate with outcomes in angiosarcomas or malignant hemangiopericytomas.
Area of Science:
- Oncology
- Pathology
- Molecular Diagnostics
Background:
- Predicting the clinical behavior of soft tissue vascular tumors based solely on histology is challenging.
- Soft tissue vascular tumors encompass a range of benign to malignant neoplasms with variable prognoses.
Purpose of the Study:
- To evaluate the utility of DNA flow cytometry in predicting the biologic behavior of soft tissue vascular tumors.
- To correlate DNA content with histological type and clinical outcomes in these neoplasms.
Main Methods:
- DNA flow cytometry was performed on paraffin-embedded tissue samples from 51 soft tissue vascular tumors.
- Tumor DNA content (ploidy) was analyzed and correlated with histological classification and patient follow-up data.
Main Results:
- Benign vascular tumors (hemangiomas, benign hemangiopericytomas) exhibited diploid DNA content.
- In angiosarcomas, 65% were diploid and 35% were aneuploid; no significant correlation was found between ploidy, histology, and clinical outcome.
- All malignant hemangiopericytomas resulted in patient death, irrespective of diploid or aneuploid DNA content.
Conclusions:
- DNA analysis demonstrates limited value in predicting the biologic behavior and clinical outcome of malignant vascular tumors of the soft tissue.
- Histological assessment remains crucial for understanding the prognosis of these tumors.