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Herpes simplex encephalitis mimicking mumps

S M al Deeb1

  • 1Department of Clinical Neurosciences, Riyadh Armed Forces Hospital, Saudi Arabia.

Clinical Neurology and Neurosurgery
|March 1, 1993
PubMed
Summary
This summary is machine-generated.

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A rare case of herpes simplex virus encephalitis in a diabetic teen caused widespread brain damage, leading to permanent pseudobulbar palsy. This unusual presentation highlights the virus's potential to affect diverse brain regions.

Area of Science:

  • Neurology
  • Virology
  • Pediatrics

Background:

  • Herpes simplex virus (HSV) encephalitis typically affects the temporal lobes.
  • Neurological complications in diabetic patients can be severe and atypical.

Observation:

  • A 16-year-old male diabetic patient presented with bilateral salivary gland swellings and subsequent encephalitis.
  • Electroencephalogram (EEG) lacked characteristic epileptic discharges.
  • Neuroimaging revealed temporal, frontal lobe, and brainstem compromise.

Findings:

  • Serology and frontal brain biopsy confirmed herpes simplex virus infection.
  • Mumps titers were insignificant, ruling out mumps as the cause.
  • The patient developed permanent pseudobulbar palsy despite delayed acyclovir treatment.

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Implications:

  • This case is exceptional due to HSV encephalitis affecting non-temporal brain regions.
  • Pseudobulbar palsy is a previously unreported sequela of HSV encephalitis.
  • Highlights the importance of considering atypical HSV presentations in immunocompromised patients.