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Plexogenic angiopathy in pulmonary intralobar sequestrations: pathogenetic mechanisms
1Department of Pathology, University of California, San Francisco 94143-0506.
Human Pathology
|March 1, 1993
Summary
Plexiform lesions in intralobar pulmonary sequestration involve vascular remodeling, angioblastic proliferation, and dilation. These changes are linked to hypoxia, inflammation, and high systemic arterial flow, offering insights into pulmonary sequestration pathology.
Area of Science:
- Pulmonary Pathology
- Vascular Biology
- Histopathology
Background:
- Intralobar pulmonary sequestration is a congenital lung malformation.
- Vascular remodeling, specifically plexiform (glomoid) lesions, is an underrecognized feature.
- These lesions occur in the context of abnormal pulmonary vasculature and altered hemodynamics.