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DXS539, a polymorphic DNA marker proximal of the fragile-X gene
J C Dreesen1, J A van den Hurk, A P Smits
1Department of Human Genetics, University Hospital Nijmegen, The Netherlands.
Human Genetics
|March 1, 1993
Abstract:
We report a new polymorphic DNA marker (pJH89, DXS539) proximal to the fragile-X site. The pJH89 probe identifies a TaqI and a NcoI restriction fragment length polymorphism (combined heterozygosity of 42%) and is linked to the fragile-X locus with a maximal LOD score of 12 at 4 cM. Multipoint linkage analysis and physical mapping studies indicate that the pJH89 probe is located within in the interval defined by the markers DXS369 and DXS548.