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Reduction of bacterial titers by low-dose aspirin in experimental aortic valve endocarditis
D P Nicolau1, C D Freeman, C H Nightingale
1Department of Pharmacy, Hartford Hospital, Connecticut 06115.
Infection and Immunity
|April 1, 1993
Abstract:
Using a rabbit model of Staphylococcus aureus endocarditis, we studied the effects of aspirin on the natural progression of this infection. Compared with untreated animals, the aspirin-treated animals showed a 30% (P = 0.11) reduction in the weight of the vegetations and an 84% (P = 0.03) reduction in the bacterial titer of the vegetations.