The adjuvant activity of saponin and aluminium hydroxide for promoting reagins

Saponin and aluminium hydroxide were compared as adjuvants for promoting serum reagins in cattle using BHK cell lysate as allergen and the passive cutaneous anaphylaxis test to demonstrate the antibodies. Saponin was the better adjuvant and provoked reagins in all the injected cattle while aluminium hydroxide did so in only 2 or 5 animals. The titres were also higher in the former case. A combination of both adjuvants stimulated reagin titres marginally higher than saponin alone while BHK cell lysate without adjuvant failed to provoke demonstrable reagins.