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Updated: Aug 9, 2026

Activation and Measurement of NLRP3 Inflammasome Activity Using IL-1β in Human Monocyte-derived Dendritic Cells
Published on: May 22, 2014
Infectious disease, interleukin-1 and central nervous system
1Department of Pharmacology and Therapeutics, University of South Florida College of Medicine.
Abstract:
Host mediators are responsible for inducing many of the nonspecific, common symptoms of illness. Several of these responses, including the induction of fever, increased levels of glucocorticoid, and increased sleep are mediated by the central nervous system (CNS). Interleukin-1 appears to be an important, but not the only, cytokine involved in activating these processes. Numerous unresolved questions remain regarding cytokine activation of the CNS, such as the neuroanatomical and neurochemical pathways involved in these responses; why these responses vary in magnitude and duration; what are the roles of individual cytokines in inducing these responses during infectious disease.
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