Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A model for macromolecular selection in complementary instructing systems

B L Jones

    Journal of Mathematical Biology
    |February 28, 1977
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Disease activity trajectories in rheumatoid arthritis: a tool for prediction of outcome.

    Scandinavian journal of rheumatology·2020
    Same author

    Under-reporting giardiasis; Time to consider the public health implications - ERRATUM.

    Epidemiology and infection·2018
    Same author

    Surface disinfection challenges for Candida auris: an in-vitro study.

    The Journal of hospital infection·2017
    Same author

    Under-reporting giardiasis: time to consider the public health implications.

    Epidemiology and infection·2017
    Same author

    An audit of Cryptosporidium and Giardia detection in Scottish National Health Service Diagnostic Microbiology Laboratories.

    Epidemiology and infection·2017
    Same author

    Restrictive antibiotic stewardship associated with reduced hospital mortality in gram-negative infection.

    QJM : monthly journal of the Association of Physicians·2016
    Same journal

    Phenotypic plasticity trade-offs in an age-structured model of bacterial growth under stress.

    Journal of mathematical biology·2026
    Same journal

    Intraspecific interactions facilitate mutualism across multilayer networks under weak selection.

    Journal of mathematical biology·2026
    Same journal

    A two-species competition model on a compact metric graph for the invasion and competition of Aedes Aegypti and Aedes Albopictus mosquitoes in Florida.

    Journal of mathematical biology·2026
    Same journal

    Superinfection and the hypnozoite reservoir for Plasmodium vivax: a multitype branching process approximation.

    Journal of mathematical biology·2026
    Same journal

    Correction to: Superinfection and the hypnozoite reservoir for Plasmodium vivax: a general framework.

    Journal of mathematical biology·2026
    Same journal

    Stoichiometric balance and sustained rhythms.

    Journal of mathematical biology·2026
    See all related articles

    This study models the selection and evolution of biological macromolecules, considering both single and double-stranded molecular complexes. It provides exact solutions for reproduction based on complementary instruction and discusses selection criteria.

    Area of Science:

    • Molecular Evolution
    • Biophysics
    • Systems Biology

    Background:

    • Eigen's original models laid groundwork for understanding molecular self-replication.
    • Previous models often simplified the structural complexity of replicating molecules.

    Purpose of the Study:

    • To extend Eigen's models by explicitly including single and double-stranded molecular complexes.
    • To analyze the selection and evolution of biological macromolecules based on complementary instruction.
    • To derive exact solutions for the underlying rate equations.

    Main Methods:

    • Development of a mathematical model incorporating both single and double-stranded molecular complexes.
    • Construction of exact solutions to the rate equations.
    • Analysis of constant rate parameters and error distributions.

    Related Experiment Videos

    Main Results:

    • The model provides a framework for understanding molecular evolution with explicit consideration of complex formation.
    • Exact solutions were derived for specific conditions of constant rates and error distributions.
    • Criteria for selection in this extended model were elucidated.

    Conclusions:

    • The extended model offers a more comprehensive view of biological macromolecule selection and evolution.
    • Complementary instruction plays a crucial role in the formation and selection of molecular complexes.
    • The derived solutions and selection criteria advance theoretical biology and biophysics.