Liver-directed superparamagnetic iron oxide: quantitation of T2 relaxation effects

¹Laboratoire de Biophysique, Faculte de Medecine, Angers, France.

|January 1, 1993

Abstract:

A new liver-directed superparamagnetic iron oxide nanoparticle preparation, MDL, is described. MDL is derived from previously developed MD particles only by modification of the characteristics of the coating:chemical structure and charge. The biodistribution, pharmacokinetics, and intratissular localization of both 59Fe-labeled MD and MDL particles were analyzed. R2 relaxivities determined in aqueous solution are compared to measurements in liver tissue and to R2 of nanoparticles incorporated into synthetic microcapsules, which represent a simplified cell pattern. T2 relaxation effects of both preparations in liver tissue are discussed relative to physical parameters such as iron oxide core dimension, total particle size, and charge, and pharmacological properties such as biodistribution, pharmacokinetics, and extra/intracellular localization.

Related Experiment Videos

Liver-directed superparamagnetic iron oxide: quantitation of T2 relaxation effects

Related Concept Videos

Antioxidants delay clinical signs and systemic effects of ENU induced brain tumors in rats.

In vitro and in vivo evaluation of superparamagnetic iron oxide nanoparticles coated by bisphosphonates: the effects of electrical charge and molecule length.

Detailed neuropsychological evaluation in a patient with Floating Harbor syndrome.

A starch-based microparticulate system dedicated to diagnostic and therapeutic nuclear medicine applications.

A 5-aza-2'-deoxycytidine/valproate combination induces cytotoxic T-cell response against mesothelioma.

Susceptibility gradient quantization by MRI signal response mapping (SIRMA) to dephaser.

Toward self-contained cardiac magnetic resonance elastography: Deep learning-based segmentation of the left ventricular myocardium.

Quantitative susceptibility mapping in neurodegenerative diseases: An umbrella review of iron-related biomarkers and mechanisms.

Ultra-high-field 5 T MRI for parotid gland assessment in Sjögren's syndrome: Improved image quality and reliable fat fraction quantification.

Measuring the vibrational response of a high performance gradient coil.

MRI-based oxygen extraction fraction mapping using qBOLD, QSM, and hybrid QSM-qBOLD methods: Methodological advances, validation, and clinical applications.

Free-breathing 3D pancreatic water T1 mapping using radial sampling technique: comparison with conventional 2D technique.

Treatment of mild cryptotia by anatomical external auricular muscle transposition without flap transfer: A case report.

Mitochondria-derived peptide hydrogel augments mitochondrial transplantation for promoting cardiac repair via macrophage metabolic reprogramming.

Inflammation-triggered sensing and miRNA immunotherapy with a wireless battery-free hydrogel bioelectronic patch.

The First Successful Capacitation In Vitro Maturation of Oocyte in Indonesia: A Promising Strategy to Enhance IVF Accessibility for Infertile Couples.

Successful Colonic Self-Expandable Metal Stent Placement Using a Rotatable Sphincterotome After Conventional Guidewire Insertion Failure: A Case Report.

A Janus dural patch constructed with hyaluronic acid bioadhesive on electrospun fibers for self-tight sealing, antibacterial and anti-tissue adhesion therapy.

Related Experiment Videos

Liver-directed superparamagnetic iron oxide: quantitation of T2 relaxation effects

Abstract:

Related Concept Videos

Related Articles