Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Analgesics abuse: theoretical and practical considerations

F Driesens1, F Awouters, T Goossens

  • 1Janssen Research Foundation, Beerse, Belgium.

Medical Hypotheses
|January 1, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Biologics for chronic rhinosinusitis with nasal polyps: a real-world prospective cohort study.

Rhinology·2026
Same author

Characterization of the long-term effects of lethal total body irradiation followed by bone marrow transplantation on the brain of C57BL/6 mice.

International journal of radiation biology·2023
Same author

Effect of viewing distance on object responses in macaque areas 45B, F5a and F5p.

Scientific reports·2022
Same author

Mental health among the Moroccan population during SARS-CoV-2 outbreak: MAROCOVID study.

Journal of affective disorders·2022
Same author

An interprofessional model of care for oral health during pregnancy.

Journal of interprofessional care·2022
Same author

The Causal Role of Three Frontal Cortical Areas in Grasping.

Cerebral cortex (New York, N.Y. : 1991)·2021

Combination painkillers are not directly linked to kidney damage; the risk stems from the pain-relieving mechanism itself, particularly non-steroidal anti-inflammatory drugs. Addressing analgesic nephropathy requires understanding drug mechanisms and societal factors.

Area of Science:

  • Nephrology
  • Pharmacology
  • Public Health

Background:

  • Analgesic nephropathy is a significant concern.
  • The role of combination painkillers in its development requires clarification.

Purpose of the Study:

  • To critically evaluate the link between combination painkillers and nephrotoxicity.
  • To examine the safety and efficacy of combination analgesics.
  • To contextualize the issue of analgesic abuse.

Main Methods:

  • Literature review and critical analysis of existing evidence.
  • Examination of pharmacological mechanisms of analgesics.
  • Socio-environmental factors influencing drug use.

Main Results:

Related Experiment Videos

  • No direct causal link established between combination painkillers and nephrotoxicity.
  • Nephrotoxicity is primarily associated with the prostaglandin-antagonizing mechanism of analgesics, especially non-steroidal anti-inflammatory drugs (NSAIDs).
  • Combination analgesics may offer advantages in activity and side-effect profiles compared to single agents.

    • Conclusions:

    • The mechanism of action, not the combination itself, is the likely cause of analgesic nephropathy.
    • Addressing analgesic abuse requires a broader focus on user personality and societal stressors, alongside preventative information campaigns.
    • Governmental intervention is needed to mitigate the broader societal factors contributing to analgesic-related problems.