Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Levodopa, parkinsonism, and recent memory

R Halgin, M Riklan, H Misiak

    The Journal of Nervous and Mental Disease
    |April 1, 1977
    PubMed
    Summary

    L-dopa treatment initially improves memory in Parkinson

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Age and sex differences in critical flicker frequency.

    Journal of experimental psychology·2010
    Same author

    Critical flicker frequency and the reversals of apparent movement in Lissajous figures.

    The American journal of psychology·2010
    Same author

    The relationship of memory and cognition in Parkinson's disease to lateralisation of motor symptoms.

    Journal of neurology, neurosurgery, and psychiatry·1990
    Same author

    Correlates of memory in Parkinson's disease.

    The Journal of nervous and mental disease·1989
    Same author

    The olfactory and cognitive deficits of Parkinson's disease: evidence for independence.

    Annals of neurology·1989
    Same author

    Depression in multiple sclerosis as a function of length and severity of illness, age, remissions, and perceived social support.

    Journal of clinical psychology·1984

    Area of Science:

    • Neuroscience
    • Neurology
    • Pharmacology

    Background:

    • Controversy exists regarding the long-term behavioral effects of L-dopa in Parkinson's disease patients.
    • The temporal limitations of L-dopa's impact on cognitive functions, particularly memory, remain unclear.
    • Understanding L-dopa's sustained efficacy is crucial for managing Parkinson's disease treatment.

    Purpose of the Study:

    • To investigate the short-term and long-term effects of L-dopa on memory in Parkinson's disease patients.
    • To compare memory performance between Parkinson's patients on L-dopa and non-parkinsonian individuals.
    • To explore the relationship between functional deficiency, symptom severity, and memory functioning in L-dopa treated patients.

    Main Methods:

    • Three groups were studied: short-term L-dopa users (≤22 months), long-term L-dopa users (≥40 months), and non-parkinsonian controls (spouses).
    • Memory was assessed using the Guild Memory Test, Memory Span for Objects, Knox Cube, and Tactile Memory Test.
    • Analysis of covariance was employed, with WAIS Vocabulary scaled score as a covariate, to analyze nine memory subtests.

    Main Results:

    • Parkinson's patients on L-dopa showed significantly different memory performance compared to non-parkinsonian subjects across all measures.
    • Short-term L-dopa patients performed significantly better than long-term L-dopa patients on six of nine memory measures, especially verbal memory.
    • Memory functioning correlated significantly with functional deficiency but not with symptom severity or L-dopa dosage.

    Conclusions:

    • The memory enhancement observed with L-dopa treatment in Parkinson's disease is not permanent.
    • The positive effects of L-dopa on memory appear to be temporally limited, diminishing with prolonged use.
    • Treatment strategies should consider the transient nature of L-dopa's cognitive benefits.

    Related Experiment Videos