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5-Lipoxygenase gene expression in HL60 cells during differentiation with DMSO
G Piechele1, S Colli, E Tremoli
1Institute of Pharmacological Sciences, University of Milan, Italy.
Pharmacological Research
|January 1, 1993
Abstract:
The model of promyelocytic leukemia cells HL60 was utilized to study the accumulation of 5-lipoxygenase mRNA during the cellular differentiation induced by DMSO. In the present study a strict correlation between the increase in state of differentiation of HL60 and accumulation of 5-lipoxygenase mRNA is demonstrated, indicating that HL60 cells are an interesting model for the study of drugs which could interfere with the synthesis of the enzyme.