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[Immunosuppressive therapy of glomerulonephritis--controlled studies]
Therapeutische Umschau. Revue Therapeutique
|February 1, 1993
Summary
Immunosuppressive therapies like glucocorticoids and cyclosporine show variable efficacy in treating glomerular diseases. Careful patient evaluation is crucial due to risks and potential for spontaneous remission.
Area of Science:
- Nephrology
- Immunology
- Pharmacology
Context:
- Glomerular diseases of immunologic origin are often treated with immunosuppressants.
- Controlled studies evaluating these therapies are essential for understanding efficacy.
Purpose:
- To analyze controlled studies on immunosuppressive therapy for glomerulonephritis.
- To assess the effectiveness of various drugs including glucocorticoids, cytostatic agents, and cyclosporine.
Summary:
- Prednisone and cyclosporine are effective for minimal-change glomerulonephritis and focal-segmental glomerulosclerosis.
- Combinations like prednisone with cyclophosphamide or azathioprine improve lupus glomerulonephritis prognosis.
- Treatment for IgA-associated and membranoproliferative glomerulonephritis lacks strong evidence.
Impact:
- Highlights the variable efficacy and significant risks of immunosuppressive therapy for glomerulonephritis.
- Emphasizes the need for individualized treatment plans considering disease prognosis and side effects.
- Suggests renal replacement therapy, including transplantation, as an alternative for some patients.