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Related Experiment Videos

Changes in seminal fluid zinc during experimental prostatitis

D E Neal1, M B Kaack, E N Fussell

  • 1Department of Urology, Tulane University School of Medicine, New Orleans, La.

Urological Research
|January 1, 1993
PubMed
Summary

Prostatitis infection leads to decreased prostatic fluid zinc (PF Zn). Zinc levels dropped during acute infection and partially recovered as the infection cleared in this study.

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Area of Science:

  • Urology
  • Infectious Diseases
  • Mineral Metabolism

Background:

  • Patients with prostatitis often exhibit reduced prostatic fluid zinc (PF Zn) levels.
  • The cause of decreased PF Zn in prostatitis remains unclear: inherent deficiency or infection-induced change.

Purpose of the Study:

  • To investigate the relationship between bacterial prostatitis and prostatic fluid zinc levels.
  • To determine if reduced PF Zn is a cause or consequence of prostatitis.

Main Methods:

  • Six nonhuman primates were experimentally infected with E. coli JR340 to induce prostatitis.
  • Prostatic fluid zinc levels were measured using colorimetric analysis post-infection.
  • Seminal fluid cultures, blood counts, renal scans, and urine cultures were monitored throughout the 4-week study.

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Main Results:

  • Experimental prostatitis led to a significant decrease in prostatic fluid zinc levels during the acute infection phase.
  • Zinc levels showed variable recovery as the prostatitis infection resolved.
  • Histopathology confirmed resolving prostatitis and fibrosis in the infected animals.

Conclusions:

  • Prostatic fluid zinc levels decrease as a direct result of the infectious process in prostatitis.
  • Reduced PF Zn is likely a consequence, not a cause, of bacterial prostatitis.