Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Bone disease in burn patients

G L Klein1, D N Herndon, T C Rutan

  • 1Department of Pediatrics, University of Texas Medical Branch, Galveston.

Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
|March 1, 1993
PubMed
Summary

Severe burn patients exhibit reduced bone turnover due to aluminum exposure and immobilization. This bone disease impacts bone formation and mineral apposition rates, affecting recovery and growth.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Associations of osteoprotegerin with coronary artery calcification among women with systemic lupus erythematosus and healthy controls.

Lupus·2018
Same author

A double-blind, randomized, Phase III, multicenter study in 358 pediatric subjects receiving isotretinoin therapy demonstrates no effect on pediatric bone mineral density.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2015
Same author

Alteration of secretion of parathyroid hormone-related peptide and expression of its mRNA in a human hepatoma cell line (HEP G2) treated with agents that affect cell growth.

Endocrine·2010
Same author

Transplantation outcomes in primary hyperoxaluria.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2010
Same author

Special report on the 2007 adult and pediatric Position Development Conferences of the International Society for Clinical Densitometry.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2008
Same author

Refractory hypercalcemia in an infant secondary to talc pleurodesis resolving after renal transplantation.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2008

Area of Science:

  • Orthopedics
  • Burn Medicine
  • Endocrinology

Background:

  • Burn patients face bone disease risks from aluminum (Al) exposure, immobilization, and corticosteroids.
  • Severely burned children experience impaired growth for up to three years post-burn.

Purpose of the Study:

  • To investigate the extent of bone disease in adult burn patients with extensive burns.
  • To assess the impact of aluminum exposure and immobility on bone turnover in burn survivors.

Main Methods:

  • Bone biopsies (iliac crest) with tetracycline labeling were performed on nine men and three women (age 18-41) with >50% body surface area burns.
  • Serial serum and urine samples were collected weekly.
  • Quantitative analysis of bone aluminum and assessment of bone formation markers were conducted.

Related Experiment Videos

Main Results:

  • Biopsied patients showed reduced bone formation, osteoid area/surface/width, and mineral apposition rate compared to healthy controls.
  • Burn patients exhibited lower bone formation, mineral apposition rate, and osteoid parameters than short-term bed rest volunteers.
  • Elevated aluminum levels were found in all patients; urine aluminum correlated inversely with serum osteocalcin. Bone aluminum was detectable in 60%.

Conclusions:

  • Burn patients demonstrate markedly reduced bone turnover, suggesting significant bone disease.
  • Etiologic factors likely include aluminum loading, partial immobilization, endogenous corticosteroids, and cytokine production.
  • These findings highlight the complex pathophysiology of bone disease in severe burn survivors.