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Selenium supplementation in intrinsic asthma

L Hasselmark1, R Malmgren, O Zetterström

  • 1Department of Experimental Surgery, Karolinska Institute, Stockholm, Sweden.

Allergy
|January 1, 1993
PubMed
Summary
This summary is machine-generated.

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Selenium supplementation in asthma patients improved glutathione peroxidase (GSH-Px) activity and clinical outcomes. This suggests selenium

Area of Science:

  • Biochemistry
  • Clinical Nutrition
  • Pulmonology

Background:

  • Asthma is linked to lower selenium (Se) levels and reduced activity of the Se-dependent enzyme glutathione peroxidase (GSH-Px).
  • GSH-Px plays a crucial role in cellular defense against oxidative stress by eliminating hydroperoxides.

Purpose of the Study:

  • To determine if selenium supplementation can enhance GSH-Px activity in asthmatic patients.
  • To assess the potential for selenium to improve clinical symptoms of asthma.

Main Methods:

  • A double-blind, placebo-controlled study involving 24 intrinsic asthma patients.
  • Patients were randomized to receive either 100 micrograms of sodium selenite or a placebo daily for 14 weeks.
  • Measurements included serum Se levels, platelet GSH-Px activity, platelet aggregation, and clinical evaluations.

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Main Results:

  • Selenium supplementation significantly increased serum Se and platelet GSH-Px activity.
  • A significant reduction in ADP-induced platelet aggregation was observed in the Se-supplemented group.
  • The Se-supplemented group showed significant overall clinical improvement compared to placebo.
  • No significant changes in lung function or airway hyperresponsiveness were detected.

Conclusions:

  • Selenium supplementation appears to be beneficial for intrinsic asthma patients by enhancing antioxidant status and improving clinical outcomes.
  • The findings support the role of GSH-Px in oxidant defense and potentially in modulating inflammatory pathways relevant to asthma.