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Increase and decrease of delayed cutaneous reactions obtained by hypnotic suggestions during sensitization. Studies

R Zachariae¹, P Bjerring

¹Institute of Psychology, University of Aarhus, Denmark.

|January 1, 1993

Summary

Hypnosis can alter immune responses. Highly suggestible individuals showed significant changes in skin reactions to chemical sensitizers like dinitrochlorobenzene (DNCB) and diphenylcyclopropenone (DCP) after hypnotic suggestions, demonstrating psychological influence on immunoreactivity.

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Area of Science:

Psychoneuroimmunology
Allergy and Immunology
Clinical Hypnosis Research

Background:

Cutaneous reactivity to chemical sensitizers is a key aspect of allergic responses.
Hypnosis has been anecdotally reported to influence physiological processes, including immune function.
Previous research suggests psychological factors can modulate immune reactivity.

Purpose of the Study:

To investigate the effect of hypnotic suggestions on cutaneous immunoreactivity to dinitrochlorobenzene (DNCB) and diphenylcyclopropenone (DCP).
To determine if individuals highly susceptible to hypnosis can modulate their immune response to specific allergens.
To explore the potential of psychological interventions in influencing allergic reactions.

Main Methods:

16 highly hypnotizable volunteers were selected using the Harvard Group Scale of Hypnotic Susceptibility.
Volunteers received hypnotic suggestions to either increase or decrease their response to DNCB and DCP sensitization.
Skin reactions were assessed via visual scoring and ultrasound measurement of skin thickness in a double-blind manner, one month post-sensitization.

Main Results:

A statistically significant difference (P < 0.01) was observed in visually scored skin reactions to DCP and DNCB between groups with opposing hypnotic instructions.
No significant difference (P = 0.055) in skin thickness, measured by ultrasound, was found between the groups.
The findings support the modulation of immunoreactivity through hypnotic suggestion.

Conclusions:

Hypnotic suggestions can significantly alter cutaneous immunoreactivity to chemical sensitizers in susceptible individuals.
This study provides evidence that specific immunological processes underlying allergic reactions may be influenced by psychological factors.
The findings contribute to the understanding of psychoneuroimmunological interactions in allergic sensitization.