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Lipoprotein(a) in patients with carotid atherosclerosis and ischemic cerebrovascular disorders
A Jovicic1, V Ivanisevic, I Ivanovic
1Clinic of Neurology, Military Medical Academy, Belgrade, Yugoslavia.
Insights
Lipoprotein(a) serum levels are higher in patients with carotid atherosclerosis and ischemic cerebrovascular disorders. While lipoprotein(a) contributes to carotid atherosclerosis, it doesn't directly cause ischemic cerebrovascular events.
Area of Science:
- Cardiovascular Medicine
- Neurology
- Biochemistry
Background:
- Lipoprotein(a) [Lp(a)] is an emerging risk factor for cardiovascular disease.
- Its role in carotid atherosclerosis and ischemic cerebrovascular disorders requires further elucidation.
Purpose of the Study:
- To investigate the association between serum lipoprotein(a) levels and carotid atherosclerosis.
- To determine the correlation between lipoprotein(a) and ischemic cerebrovascular disorders.
Main Methods:
- Serum Lp(a) concentrations were measured in 49 patients with transient ischemic attacks, 61 with acute cerebral infarction, 48 with asymptomatic carotid atherosclerosis, and 50 healthy controls.
- Clinical parameters, including the degree of carotid atherosclerosis, were analyzed for correlations with Lp(a) levels.
Main Results:
- Significantly higher serum Lp(a) levels were observed in patients compared to healthy subjects.
- A positive correlation was found between serum Lp(a) levels and the severity of carotid atherosclerosis.
- Lp(a) levels showed associations with other clinical parameters, detailed within the study.
Conclusions:
- Lipoprotein(a) plays a role in the pathogenesis of carotid atherosclerosis.
- However, Lp(a) is not directly associated with the development of ischemic cerebrovascular disorders.
Abstract:
The aim of this study was to evaluate the role of lipoprotein(a) in the carotid atherosclerosis and ischemic cerebrovascular disorders. Four groups of subjects were included: 49 patients with transient ischemic attacks, 61 with acute cerebral infarction, 48 with asymptomatic carotid atherosclerosis and a group of 50 healthy subjects. Lipoprotein(a) serum concentration and its correlation with various clinical parameters was analysed. The results revealed a significant difference between lipoprotein(a) serum levels in patients and healthy subjects and positive correlation between lipoprotein(a) serum levels and the degree of carotid atherosclerosis. Moreover, some other correlations are found and discussed. It was concluded that lipoprotein(a) is involved in the pathogenesis of carotid atherosclerosis, but it is not associated with the development of ischemic cerebrovascular disorders.