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Related Experiment Videos

Mal de Meleda keratoderma with pseudoainhum

R Bergman1, O Bitterman-Deutsch, M Fartasch

  • 1Department of Dermatology, Rambam Medical Center, Haifa, Israel.

The British Journal of Dermatology
|February 1, 1993
PubMed
Summary
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Pseudoainhum, a complication of mal de Meleda keratoderma, can threaten digit viability. Early treatment with etretinate in a child successfully preserved finger function, highlighting a treatment option for this rare condition.

Area of Science:

  • Dermatology
  • Genetics
  • Pediatrics

Background:

  • Pseudoainhum is a rare complication associated with autosomal-recessive keratodermas.
  • Mal de Meleda keratoderma is an autosomal-recessive skin disorder characterized by palmoplantar keratoderma.

Observation:

  • Two families with genetically confirmed mal de Meleda keratoderma were studied.
  • A 9-year-old girl presented with pseudoainhum affecting her little fingers, jeopardizing their viability.

Findings:

  • The patient's pseudoainhum responded favorably to treatment with etretinate.
  • Ultrastructural findings supported the diagnosis of mal de Meleda keratoderma.

Implications:

  • This case highlights the potential efficacy of etretinate in managing pseudoainhum secondary to keratoderma in children.

Related Experiment Videos

  • The study discusses the therapeutic dilemma between systemic retinoid toxicity and surgical risks for keratoderma-induced pseudoainhum in pediatric patients.