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Colitis in children with the hemolytic-uremic syndrome
Journal of Pediatric Surgery
|April 1, 1977
Summary
Hemolytic-uremic syndrome (HUS) can present with gastrointestinal issues like thumbprinting on colon imaging. These findings, though uncommon, suggest HUS in children with bloody diarrhea, guiding diagnostic and surgical decisions.
Area of Science:
- Pediatric Gastroenterology
- Nephrology
- Diagnostic Imaging
Background:
- Hemolytic-uremic syndrome (HUS) is a serious condition characterized by hemolytic anemia, renal failure, and thrombocytopenia.
- Gastrointestinal manifestations are known in HUS, but specific colonic lesions are less commonly emphasized.
Observation:
- Submucosal hemorrhage with "thumbprinting" on barium enema was observed in four patients.
- Rectal prolapse and toxic megacolon were noted in other HUS patients.
- These colonic findings are not typically associated with HUS.
Findings:
- The presence of these colonic lesions in children with bloody diarrhea should raise suspicion for HUS.
- Diagnostic procedures like sigmoidoscopy and barium enema are valuable in assessing colonic involvement in HUS.
Implications:
- Early recognition of these gastrointestinal signs can aid in diagnosing HUS.
- Evaluation of colonic involvement is crucial for determining appropriate management, including potential surgical intervention.