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Cholecystokinin receptor density in the striatum of the spontaneously hypertensive rat
1Division of Cardiovascular Sciences, St. Boniface Hospital Research Centre, Faculty of Medicine, University of Manitoba, Winnipeg, Canada.
Abstract:
The possibility that cholecystokinin in the striatum may be involved in hypertension was investigated using in vitro receptor autoradiography. The binding density of 125I-Bolton Hunter labeled cholecystokinin octapeptide (125I-BH-CCK8) was determined using computer-assisted densitometry in the striatum of the spontaneously hypertensive rat (SHR) and its control the Wistar-Kyoto rat (WKY). A significant increase in 125I-BH-CCK8 binding density was found in the lateral part of the caudate-putamen of the SHR. In contrast, a significant decrease in 125I-BH-CCK8 binding density was found in the posteromedial nucleus accumbens of the SHR. These results indicate that CCK8 receptor density is altered in the striatum of the SHR and suggest a role for CCK8 receptors in the pathophysiology of hypertension.