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Persistent pulmonary hypertension of the newborn. The black box revisited
1Case Western Reserve University School of Medicine, Cleveland, Ohio.
Insights
Neonatal pulmonary hypertension therapies require rigorous study. Well-designed trials are essential to guide future treatment of persistent pulmonary hypertension of the newborn (PPHN).
Area of Science:
- Neonatology
- Pediatric Critical Care
Background:
- Current management of persistent pulmonary hypertension of the newborn (PPHN) is influenced by clinical uncertainty and a desire to provide optimal care.
- There is a need to move beyond well-intentioned but unstudied therapeutic approaches in neonatology.
Purpose of the Study:
- To advocate for the initiation of thoughtful, well-designed clinical studies in PPHN.
- To emphasize the necessity of evidence-based practices in neonatal care.
Main Methods:
- The abstract calls for multicentered trials to resolve treatment controversies.
- It stresses the importance of rigorous scientific methodology.
Main Results:
- The abstract does not present study results but rather a call to action.
Conclusions:
- The current understanding and treatment of PPHN necessitate a shift towards evidence-based medicine.
- Multicentered trials are crucial to address existing controversies and advance PPHN management.
Abstract:
Our understanding and therapy of PPHN, as in many other aspects of neonatology, have been clouded by our understandable fear for our patients and our wish to provide excellent care. We can no longer accept therapies that are well intentioned but unstudied. It is time that thoughtful, well-designed studies be conducted to lead us into the next century. The controversies surrounding treatment can be answered in multicentered trials. We must accept this challenge.