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Updated: Aug 6, 2026

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Intravascular Delivery of Biologics to the Rat Kidney
Published on: September 1, 2016
Pathology of recombinant human transforming growth factor-beta 1 in rats and rabbits
T G Terrell1, P K Working, C P Chow
1Department of Safety Evaluation, Genentech, Inc., South San Francisco, California 94080.
Abstract:
The systemic administration of high doses of rHuTGF-beta 1 to rats produced a spectrum of lesions in multiple target tissues, including liver, bone, kidney, heart, thymus, pancreas, stomach, cecum, at the injection vein, and in skeletal muscle at the site of anesthetic injection. The majority of these lesions can be attributed to known biological activities of TGF-beta 1. High-dose dermal application resulted in local effects at the wound sites without systemic toxicity.

