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Estimating fertility potential via semen analysis data

B Bartoov1, F Eltes, M Pansky

  • 1Health Science Research Centre, Bar-Ilan University, Ramat Gan, Israel.

Human Reproduction (Oxford, England)
|January 1, 1993
PubMed
Summary
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Evaluating male fertility potential requires a comprehensive semen analysis. Combining semen volume, sperm count, motility, and morphology offers high accuracy but needs new parameters for improved prognostic potential in fertility assessments.

Area of Science:

  • Reproductive Medicine
  • Andrology
  • Clinical Diagnostics

Background:

  • Male infertility affects a significant portion of couples seeking fertility treatment.
  • Conventional semen analysis is crucial for assessing male reproductive health.
  • Existing diagnostic profiles for semen analysis require further validation for accurate fertility prediction.

Purpose of the Study:

  • To evaluate diagnostic profiles for semen analysis data in relation to male fertility potential.
  • To assess the validity of World Health Organization (WHO) standard values for semen analysis.
  • To explore the predictive value of individual semen characteristics versus combined indices.

Main Methods:

  • Conventional semen analysis performed on 208 patients with known fertility or suspected infertility.

Related Experiment Videos

  • Evaluation of diagnostic approaches including deviation from WHO standards and specific semen characteristics.
  • Development and testing of a semen analysis index combining multiple parameters.

    • Main Results:

    • The number of deviations from WHO standards showed limited validity for fertility assessment.
    • Specific semen characteristics, like morphology, were not superior predictors of fertility.
    • A semen analysis index combining volume, count, motility, and morphology achieved high classification accuracy in 44% of cases.
    • The index yielded 3% false negatives and 10% false positives with defined cut-off values.

    Conclusions:

    • Optimal evaluation of male fertility status relies on a combination of specific semen analysis variables.
    • Current semen analysis parameters, when appropriately combined, provide valuable insights into fertility potential.
    • Discovery of novel and meaningful parameters is essential to enhance the prognostic capability of semen analysis for male fertility.