Enteric adenovirus infection among infants with diarrhea in rural Bangladesh

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Published on: June 10, 2021

K Jarecki-Khan1, S R Tzipori, L E Unicomb

  • 1International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka.

Journal of Clinical Microbiology
|March 1, 1993
PubMed

Insights

Enteric adenoviruses (EAds), specifically types 40 and 41, are common causes of diarrhea in Bangladeshi infants. These infections present with symptoms similar to rotavirus, leading to mild to moderate dehydration.

Area of Science:

  • Virology
  • Pediatrics
  • Public Health

Background:

  • Diarrheal diseases are a major cause of infant mortality globally.
  • Adenoviruses are recognized as a significant pathogen contributing to gastroenteritis in children.
  • Limited data exists on the specific types and prevalence of enteric adenoviruses in developing regions like Bangladesh.

Purpose of the Study:

  • To determine the prevalence and types of adenoviruses in infants with diarrhea in Matlab, Bangladesh.
  • To characterize the clinical features and demographic data associated with adenovirus infections.
  • To compare adenovirus infection symptoms with those of rotavirus.

Main Methods:

  • Enzyme immunoassay (EIA) was used to detect adenoviruses in 4,409 stool specimens from infants.
  • Positive samples were serotyped using monoclonal antibodies for adenovirus types 40 (Ad40) and 41.
  • Cell culture and EIA retesting confirmed enteric adenovirus (EAd) identification.

Main Results:

  • Enteric adenoviruses (EAds) were detected in 2.8% of specimens (125/4,409).
  • Adenovirus type 41 was more prevalent (59.2%) than type 40 (40.8%).
  • Common symptoms included watery diarrhea, frequent loose stools, vomiting, abdominal pain, and low-grade fever, similar to rotavirus infections.

Conclusions:

  • Enteric adenoviruses, particularly types 40 and 41, are significant contributors to infantile diarrhea in Bangladesh.
  • The clinical presentation of EAd infection closely mimics rotavirus gastroenteritis.
  • Further research into the epidemiology and management of EAd in this region is warranted.

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