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Neoplastic association of enhanced type V collagen production in rat fibrosarcoma
R Asokan1, G K Reddy, S C Dhar
1Department of Biochemistry, Central Leather Research Institute, Madras, India.
Molecular and Cellular Biochemistry
|March 10, 1993
Abstract:
Collagens present in the connective tissues of the extracellular matrix of fibrosarcoma were isolated and characterized. The fibrosarcoma was induced in rats by the administration of 3-methylcholanthrene. The results obtained were compared with normal muscle. An excess amount of type V collagen was found to be produced by the fibrosarcoma tissue compared to the normal muscle. Type V collagen from fibrosarcoma was characterized on the basis of solubility behavior in sodium chloride solutions, electrophoretic mobility on SDS-polyacrylamide gels, elution pattern of phosphocellulose chromatography and amino acid composition.