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MRI in craniofacial fibrous dysplasia
J W Casselman1, I De Jonge, L Neyt
1Department of Radiology, St. Jan Hospital, Bruges, Belgium.
Abstract:
Five patients with biopsy-proven craniofacial fibrous dysplasia underwent MRI with T1- and T2-weighted sequences and a gadolinium-enhanced T1-weighted spin-echo sequence. Low to intermediate signal intensity was usually seen in the largest part of the lesion on both spin-echo sequences, but smaller regions of hyperintensity on T1- and T2-weighted images and intermediate signal intensity throughout a lesion on T1-weighted images were also seen. All lesions enhanced but only two became iso- or hyperintense compared to fat. High clinical and pathological activity in three cases correlated with high signal intensity on both spin-echo sequences and with strong enhancement in two of the three. The presence of large veins or sinusoids on pathological examination did not correlate with the enhancement pattern.
Insights
Craniofacial fibrous dysplasia MRI shows varied signal intensities and enhancement patterns. High activity correlates with specific MRI findings, aiding diagnosis.
Area of Science:
- Radiology
- Medical Imaging
- Oncology
Background:
- Craniofacial fibrous dysplasia (CFD) is a rare bone disorder.
- Accurate diagnosis and assessment of disease activity are crucial for patient management.
Purpose of the Study:
- To evaluate the magnetic resonance imaging (MRI) characteristics of craniofacial fibrous dysplasia.
- To correlate imaging findings with histopathological activity.
Main Methods:
- MRI including T1- and T2-weighted sequences and gadolinium-enhanced T1-weighted spin-echo sequence was performed in five patients.
- Histopathological analysis was used to assess lesion activity.
Main Results:
- Lesions typically showed low to intermediate signal intensity on spin-echo sequences.
- All lesions enhanced with gadolinium, but only two became isointense or hyperintense compared to fat.
- High clinical and pathological activity correlated with high signal intensity and strong enhancement in three cases.
Conclusions:
- MRI demonstrates diverse signal intensities and enhancement patterns in craniofacial fibrous dysplasia.
- Specific MRI features may correlate with disease activity, aiding in diagnosis and treatment planning.