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Intermediate-duration toxicity study of patulin in rats
Journal of Toxicology and Environmental Health
|January 1, 1977
Summary
Patulin mycotoxin exposure in Sprague-Dawley rats caused reduced weight gain and impaired growth in offspring. No significant teratogenic effects were observed at lower doses, but higher doses led to mortality.
Area of Science:
- Toxicology
- Mycotoxicology
- Reproductive Toxicology
Background:
- Patulin is a mycotoxin found in moldy fruits and food products.
- Understanding patulin's toxicity is crucial for food safety and public health.
Purpose of the Study:
- To evaluate the toxicity of patulin in Sprague-Dawley rats across two generations.
- To determine dose-related effects and identify potential teratogenic or reproductive impacts.
Main Methods:
- Administration of patulin (0, 1.5, 7.5, 15.0 mg/kg) via gavage to Sprague-Dawley rats over 10 months.
- Two generations (F0, F1A, F2A) were studied, with specific dosing regimens during pregnancy.
- Necropsy and teratological examinations were performed on fetuses and adult rats.
Main Results:
- High mortality and reduced progeny observed at 7.5 and 15.0 mg/kg patulin doses.
- Dose-related decreased weight gain in F0 male rats and statistically significant growth impairment in F1A and F2A progeny at 1.5 mg/kg.
- Fetal growth retardation observed, particularly in F2A males, with no consistent teratological abnormalities at 1.5 mg/kg.
- No dominant lethal effects were noted up to 15.0 mg/kg.
Conclusions:
- Patulin exhibits dose-dependent toxicity, affecting growth and reproduction in rats.
- Lower doses (1.5 mg/kg) caused growth impairment without significant teratogenicity.
- Higher patulin doses are lethal and severely impact reproductive success.