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Related Experiment Videos

Tuberculous subcutaneous abscesses developing during chemotherapy for pulmonary tuberculosis

C H Chen1, J J Tsai, J F Shih

  • 1Department of Chest Medicine, Veterans General Hospital-Taipei, Taiwan.

Scandinavian Journal of Infectious Diseases
|January 1, 1993
PubMed
Summary

Military tuberculosis can manifest as skin lesions during treatment in systemic lupus erythematosus patients. These lesions do not always indicate treatment failure and can resolve with continued therapy.

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Area of Science:

  • Infectious Diseases
  • Dermatology
  • Rheumatology

Background:

  • Systemic lupus erythematosus (SLE) is an autoimmune disease increasing susceptibility to infections.
  • Tuberculosis (TB) is a significant opportunistic infection in immunocompromised individuals.
  • Disseminated tuberculosis, including military patterns, can present with diverse clinical manifestations.

Observation:

  • A 32-year-old woman with SLE developed military tuberculosis.
  • Multiple subcutaneous abscesses, confirmed as Mycobacterium tuberculosis, appeared during initial antituberculosis therapy.
  • Skin lesions emerged despite susceptibility of the Mycobacterium tuberculosis strain to all prescribed antituberculosis drugs.

Findings:

  • Complete resolution of both pulmonary and cutaneous tuberculous lesions was achieved.

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  • Continuous antituberculosis therapy led to the disappearance of skin abscesses.
  • The emergence of skin lesions did not signify therapeutic failure.

    • Implications:

    • Tuberculous skin lesions can occur during standard antituberculosis treatment, even with susceptible strains.
    • Clinical presentation of tuberculosis in SLE patients can be atypical.
    • Close monitoring and continued treatment are crucial for managing disseminated tuberculosis in immunocompromised patients, even with evolving symptoms.