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Mapping of the genes for human endoplasmic reticular heat shock protein gp96/grp94

R G Maki1, R L Eddy, M Byers

  • 1Department of Pharmacology, Mount Sinai School of Medicine, CUNY, New York 10029.

Somatic Cell and Molecular Genetics
|January 1, 1993
PubMed

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Exon Recombination02:32

Exon Recombination

The evolution of new genes is critical for speciation. Exon recombination, also known as exon shuffling or domain shuffling, is an important means of new gene formation. It is observed across vertebrates, invertebrates, and in some plants such as potatoes and sunflowers. During exon recombination, exons from the same or different genes recombine and produce new exon-intron combinations, which might evolve into new genes. 
Exon shuffling follows “splice frame rules.” Each exon has three reading...