Effects of ATP on Rb86 clearance of the various organs in rats

Thirty-seven normal rats were used to investigate the effect of ATP on Rb86 clearance of the various organs. Blood pressure was decreased by intravenous bolus injection of 10 or 50 mug ATP/Kg body weight (b.w.). In 10 mug ATP/Kg b.w. infusion, Rb86 clearance of the heart, liver, and pancreas was increased by 43, 29, and 27% respectively. In 50 mug ATP/Kg b.w. infusion which reduced the arterial blood pressure strikingly, Rb86 clearance of the liver and pancreas was increased; and that of the kidney was decreased significantly. The present study may suggest that the effective nutritional blood flow of the heart, liver, and pancreas is increased by intravenous infusion of 10 mug ATP/Kg b.w.