Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cancer genes

P K Vogt1

  • 1Department of Microbiology, University of Southern California, School of Medicine, Los Angeles 90033.

The Western Journal of Medicine
|March 1, 1993
PubMed
Summary
This summary is machine-generated.

Cancer arises from genetic alterations in oncogenes and tumor suppressor genes. These gene classes regulate cell growth, and their dysfunction drives cancer development and progression through accumulated mutations.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Class I PI3K in oncogenic cellular transformation.

Oncogene·2008
Same author

Constitutively active Rheb induces oncogenic transformation.

Oncogene·2008
Same author

Oncogenic signaling of class I PI3K isoforms.

Oncogene·2007
Same author

Phosphorylation by Akt disables the anti-oncogenic activity of YB-1.

Oncogene·2007
Same author

A short N-terminal sequence of PTEN controls cytoplasmic localization and is required for suppression of cell growth.

Oncogene·2007
Same author

Retroviral oncogenes and TOR.

Current topics in microbiology and immunology·2003

Area of Science:

  • Genetics
  • Molecular Biology
  • Oncology

Background:

  • Cancer is fundamentally a genetic disease driven by alterations in growth-regulatory genes.
  • Two key gene classes involved are oncogenes (positive growth regulators) and tumor suppressor genes (negative growth regulators).
  • Dysregulation of these genes, through gain-of-function (oncogenes) or loss-of-function (tumor suppressor genes) mutations, contributes to cancer initiation and progression.

Purpose of the Study:

  • To elucidate the roles of oncogenes and tumor suppressor genes in cancer development.
  • To explain how genetic alterations in these genes lead to uncontrolled cell growth.
  • To highlight the significance of these genetic insights for developing targeted cancer therapies.

Main Methods:

  • The abstract does not detail specific experimental methods but discusses genetic alterations and their functional consequences.

Related Experiment Videos

  • It reviews the established roles of oncogenes and tumor suppressor genes based on existing research.
  • The text synthesizes knowledge on how mutations in these genes contribute to oncogenesis.

    • Main Results:

    • Genetic alterations in oncogenes and tumor suppressor genes are central to cancer.
    • Oncogenes promote aberrant growth via gain-of-function mutations.
    • Tumor suppressor genes inhibit growth; their inactivation through mutations or deletions leads to cancer.

    Conclusions:

    • Cancer results from the accumulation of genetic changes in both oncogenes and tumor suppressor genes.
    • Understanding these gene classes provides critical insights into cell growth regulation.
    • This knowledge is pivotal for developing novel, gene-specific cancer therapies.