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Sedation with propofol during surgery under local blockade. Assessment of a target-controlled infusion system
I G Skipsey1, J R Colvin, N Mackenzie
1Department of Anaesthesia, Ninewells Hospital and Medical School, Dundee.
Abstract:
The ability of a target-controlled propofol infusion system to provide sedation for 40 patients undergoing surgery under regional blockade was assessed. Eighty-eight per cent of the total infusion time was at the desired sedation level with little oversedation. This was achieved with a median blood propofol concentration of 0.93 micrograms.ml-1. The pharmacokinetic algorithm performed as well when used for sedation as for total intravenous anaesthesia. The predicted and measured blood propofol concentrations showed a bias of -12% and a precision of 34%.
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