Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Phenotyping. On reaching base camp (1950-1975)

D S Fredrickson1

  • 1National Library of Medicine, National Institutes of Health, Bethesda, Md 20892.

Circulation
|April 1, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The first twenty-five years after Asilomar.

Perspectives in biology and medicine·2001
Same author

Complete genomic sequence of the human ABCA1 gene: analysis of the human and mouse ATP-binding cassette A promoter.

Proceedings of the National Academy of Sciences of the United States of America·2000
Same author

Human ATP-binding cassette transporter 1 (ABC1): genomic organization and identification of the genetic defect in the original Tangier disease kindred.

Proceedings of the National Academy of Sciences of the United States of America·1999
Same author

James Augustine Shannon (9 August 1904-20 May 1994).

Proceedings of the American Philosophical Society·1996
Same author

10th Anniversary Colloquium. Medicine, public health, and environment.

Issues in science and technology·1995
Same author

The heart in Tangier disease. Severe coronary atherosclerosis with near absence of high-density lipoprotein cholesterol.

American journal of clinical pathology·1992
Same journal

Deprescribing in Patients With Cardiovascular Disease Experiencing Polypharmacy: A Scientific Statement From the American Heart Association.

Circulation·2026
Same journal

A Bundle to Frame Guidelines and American Heart Association Statements.

Circulation·2026
Same journal

<i>Circulation</i> Editors and Editorial Board.

Circulation·2026
Same journal

A New <i>Circulation</i>, For You.

Circulation·2026
Same journal

Cardiovascular Risk Reduction With GLP-1 RA Drugs.

Circulation·2026
Same journal

Obesity, Severe Obesity, and Abdominal Obesity in US Youth and Adults From 1999 to 2023.

Circulation·2026
See all related articles

The discovery of plasma lipoproteins evolved from early separation techniques to understanding their role in cardiovascular disease. Research advanced from analytical ultracentrifugation to molecular biology, identifying apolipoproteins and receptors.

Area of Science:

  • Biochemistry
  • Cardiovascular Research
  • Genetics

Background:

  • The study traces the historical progression of lipoprotein research, beginning with early separation methods in the mid-20th century.
  • Initial focus was on differentiating alpha and beta lipoproteins, later termed high-density lipoprotein (HDL) and low-density lipoprotein (LDL).

Discussion:

  • The evolution of lipoprotein research involved a shift from analytical ultracentrifugation to understanding the biological roles of lipoproteins and their associated enzymes like lipoprotein lipase.
  • Genetic disorders such as abetalipoproteinemia and Tangier disease highlighted the significance of specific apolipoproteins, driving research into their structure and function.
  • The classification of hyperlipoproteinemia and the development of diagnostic tools like the Friedewald formula marked significant advancements in identifying genetic links to coronary artery disease.

Related Experiment Videos

Key Insights:

  • The identification of the low-density lipoprotein receptor revolutionized the understanding of lipoprotein metabolism and genetic dyslipoproteinemias.
  • Early research established cholesterol and Sf 0-20 levels as risk factors, later refined by understanding apolipoprotein specificity and genetic influences.
  • The convergence of molecular biology with lipoprotein research provided deeper insights into dyslipoproteinemia and atherosclerosis.

Outlook:

  • Future research directions involve integrating molecular biology findings with existing knowledge of lipoproteins, dyslipoproteinemia, and atherosclerosis.
  • Continued investigation into the genetic underpinnings of lipid disorders is crucial for developing targeted therapies.
  • Understanding the complex interplay between lipoproteins and cardiovascular health remains a key focus for disease prevention and management.