Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Multimodality therapy for esophageal carcinoma--update

M B Orringer1

  • 1Section of Thoracic Surgery, University of Michigan Medical Center, Ann Arbor.

Chest
|April 1, 1993
PubMed
Summary

Transhiatal esophagectomy offers a less invasive approach for esophageal cancer palliation, reducing complications. Preoperative chemoradiation significantly improves survival rates compared to surgery alone.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Worldwide Esophageal Cancer Collaboration: pathologic staging data.

Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus·2016
Same author

Worldwide Esophageal Cancer Collaboration: neoadjuvant pathologic staging data.

Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus·2016
Same author

Worldwide Esophageal Cancer Collaboration: clinical staging data.

Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus·2016
Same author

Decreased core muscle size is associated with worse patient survival following esophagectomy for cancer.

Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus·2013
Same author

Genomic amplification of MET with boundaries within fragile site FRA7G and upregulation of MET pathways in esophageal adenocarcinoma.

Oncogene·2005
Same author

Esophagectomy for achalasia: patient selection and clinical experience.

The Annals of thoracic surgery·2001

Area of Science:

  • Surgical Oncology
  • Gastroenterology
  • Thoracic Surgery

Background:

  • Transhiatal esophagectomy with gastric pull-up has been a standard palliative treatment for dysphagia for over 15 years.
  • This technique is considered preferable to the traditional transthoracic approach due to reduced complications.

Purpose of the Study:

  • To evaluate the efficacy and safety of transhiatal esophagectomy.
  • To assess the impact of preoperative chemoradiation on survival outcomes in esophageal cancer patients.

Main Methods:

  • A retrospective analysis of transhiatal esophagectomy outcomes.
  • A Phase II trial involving preoperative chemoradiation (cisplatin, vinblastine, 5-fluorouracil) followed by esophagectomy.

Main Results:

  • Transhiatal esophagectomy demonstrated reduced pulmonary complications and mediastinitis compared to transthoracic approaches.
  • The Phase II trial showed a 3-year survival of 46% with chemoradiation and surgery versus 23% with surgery alone.
  • Complete responders in the trial achieved a 5-year survival of 70%.

Conclusions:

  • Transhiatal esophagectomy is a safe and effective procedure for esophageal cancer palliation.
  • Preoperative chemoradiation significantly enhances survival in esophageal cancer patients undergoing esophagectomy.

Related Experiment Videos