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Microalbuminuria in NIDDM
M M Bashyam1, N J O'Sullivan, H H Baker
1Department of Medicine, Cork Regional Hospital, Wilton, Ireland.
Diabetes Care
|April 1, 1993
Summary
Neither Micro-Bumintest nor Micral-Test effectively screens for microalbuminuria in patients with non-insulin-dependent diabetes mellitus (NIDDM). Further research is needed to identify a reliable screening method for this condition.
Area of Science:
- Nephrology
- Diabetology
- Clinical Chemistry
Background:
- Diabetic nephropathy is a major complication of non-insulin-dependent diabetes mellitus (NIDDM).
- Early detection of microalbuminuria is crucial for managing diabetic nephropathy.
- Routine urine tests may not detect early stages of microalbuminuria.
Purpose of the Study:
- To evaluate the effectiveness of Micro-Bumintest and Micral-Test as screening procedures for microalbuminuria in NIDDM patients.
- To determine if these tests can identify patients with microalbuminuria missed by standard urine dipstick testing.
Main Methods:
- A study was conducted on 128 NIDDM patients with initially negative routine urine tests for albumin.
- Microalbuminuria was assessed using overnight urine samples collected on at least two occasions over six months.
- Patients were tested using Micro-Bumintest and Micral-Test.
Main Results:
- Ten patients (7.8%) showed albumin concentrations >= 20 mg/L on two or more occasions.
- Fourteen patients (10.9%) had albumin-to-creatinine (A-C) ratios >= 3 mg/M on two or more occasions.
- Nine patients (7.0%) met both criteria.
Conclusions:
- Micro-Bumintest and Micral-Test are not effective or feasible screening methods for microalbuminuria in NIDDM patients.
- These tests failed to reliably identify individuals with microalbuminuria.
- The study highlights the need for improved screening strategies for microalbuminuria in diabetic populations.