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Hereditary hydronephrosis in C57L/MsNrs mice
1Department of Veterinary Science, National Institute of Health, Tokyo, Japan.
Jikken Dobutsu. Experimental Animals
|January 1, 1993
Summary
C57L mice exhibit hydronephrosis without sex or age differences, with the right kidney more affected. This finding contrasts with previously studied hydronephrotic mouse strains, offering new insights into kidney disease development.
Area of Science:
- Nephrology
- Genetics
- Animal Models
Background:
- Hydronephrosis, a condition of kidney swelling, is often studied in specific mouse strains.
- Previous research has indicated sex-related differences in hydronephrosis incidence and severity in certain mouse models.
Purpose of the Study:
- To investigate the incidence and severity of hydronephrosis in inbred C57L/MsNrs mice.
- To determine if there are sex-related differences in hydronephrosis in this specific mouse strain.
- To assess the influence of age on hydronephrosis incidence.
Main Methods:
- Gross examination of kidneys for hydronephrosis in a cohort of C57L/MsNrs mice (66 males, 72 females).
- Statistical analysis to compare incidence and severity between sexes and assess age influence.
Main Results:
- C57L mice showed no significant sex-related difference in hydronephrosis incidence (62% males, 75% females; P > 0.05).
- The right kidney was more severely affected than the left kidney in both sexes.
- Hydronephrosis incidence was not influenced by age in this study population.
Conclusions:
- Inbred C57L/MsNrs mice present a unique model for hydronephrosis research, lacking typical sex-based variations.
- The right kidney predilection warrants further investigation into underlying mechanisms.
- This strain provides a valuable tool for studying hydronephrosis pathogenesis independent of sex-related factors.