Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Complex function and expression of Delta during Drosophila oogenesis

L B Bender1, P J Kooh, M A Muskavitch

  • 1Department of Biology, Indiana University, Bloomington 47405.

Genetics
|April 1, 1993
PubMed
Summary

The Delta protein is crucial for cell interactions during fruit fly development. Mutations in Delta cause developmental defects and sterility in female fruit flies, impacting egg chamber formation.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

neuralized Encodes a peripheral membrane protein involved in delta signaling and endocytosis.

Developmental cell·2001
Same author

Ligand endocytosis drives receptor dissociation and activation in the Notch pathway.

Development (Cambridge, England)·2000
Same author

Engineered truncations in the Drosophila mastermind protein disrupt Notch pathway function.

Developmental biology·1999
Same author

Ligand-receptor interactions and trans-endocytosis of Delta, Serrate and Notch: members of the Notch signalling pathway in Drosophila.

Journal of cell science·1999
Same author

Cis-interactions between Delta and Notch modulate neurogenic signalling in Drosophila.

Development (Cambridge, England)·1998
Same author

Complex proteolytic processing acts on Delta, a transmembrane ligand for Notch, during Drosophila development.

Molecular biology of the cell·1998

Area of Science:

  • Developmental Biology
  • Cell Biology
  • Genetics

Background:

  • The Delta (Dl) protein mediates cell-cell interactions essential for cell fate specification in Drosophila melanogaster.
  • Understanding Delta's role is key to deciphering developmental processes.

Purpose of the Study:

  • To investigate the expression patterns of Delta during oogenesis.
  • To correlate Delta expression with observed morphogenetic defects in Delta mutants.
  • To compare Delta and Notch protein expression during oogenesis.

Main Methods:

  • Histochemical analysis of Delta protein expression during oogenesis stages 1-10.
  • Correlation of Delta expression with morphogenetic defects in Delta mutant females.
  • Comparative analysis of Delta and Notch protein expression patterns in the ovary.

Related Experiment Videos

Main Results:

  • Delta protein is expressed intermittently in follicle and germ-line cells during oogenesis.
  • Delta mutations are linked to defects in germarium stalk formation, egg chamber fusion, germ-line cell necrosis, and embryonic arrest.
  • Delta and Notch proteins show significant, though not complete, overlap in expression patterns during oogenesis.

Conclusions:

  • Delta plays a critical role in cell-cell interactions governing cell fate specification during Drosophila oogenesis.
  • Observed defects in Delta mutants highlight its importance in normal oogenesis progression and fertility.
  • The interplay between Delta and Notch signaling pathways warrants further investigation in the context of oogenesis.