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[Pemphigus foliaceus caused by penicillamine]

D Zillikens1, A Zentner, M Burger

  • 1Universitäts-Hautklinik Würzburg.

Der Hautarzt; Zeitschrift Fur Dermatologie, Venerologie, Und Verwandte Gebiete
|March 1, 1993
PubMed
Summary

An 80-year-old woman developed pemphigus foliaceus while on penicillamine for rheumatoid arthritis. This case offers new insights into drug-induced pemphigus and lists causative agents.

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Area of Science:

  • Dermatology
  • Rheumatology
  • Pharmacology

Background:

  • Pemphigus foliaceus is a rare autoimmune blistering disease.
  • Penicillamine is a chelating agent used for rheumatoid arthritis and other conditions.
  • Drug-induced autoimmune diseases are a growing concern in clinical practice.

Observation:

  • An 80-year-old female patient developed pemphigus foliaceus.
  • The patient was undergoing treatment with penicillamine for rheumatoid arthritis.
  • The onset of pemphigus foliaceus coincided with penicillamine therapy.

Findings:

  • This case highlights penicillamine as a potential trigger for pemphigus foliaceus.
  • The report provides novel insights into the pathogenesis of drug-induced pemphigus.

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  • A comprehensive literature review identifies various drugs associated with inducing pemphigus.

    • Implications:

    • Clinicians should consider drug-induced pemphigus in patients presenting with new-onset blistering disorders.
    • Awareness of penicillamine's potential side effect is crucial for rheumatologists.
    • Further research into the mechanisms of drug-induced autoimmunity may lead to safer therapeutic strategies.