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[Metastasizing eccrine porocarcinoma]

K Langfritz1, S Grabbe, G Kovacs

  • 1Hautklinik, Universität Münster.

Der Hautarzt; Zeitschrift Fur Dermatologie, Venerologie, Und Verwandte Gebiete
|March 1, 1993
PubMed
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Metastasizing eccrine porocarcinoma, a rare skin cancer, presented as skin nodules and leg lymphedema. Early misdiagnosis as actinic keratosis delayed treatment, leading to a fatal outcome despite radiation therapy.

Area of Science:

  • Dermatology
  • Oncology
  • Pathology

Background:

  • Eccrine porocarcinoma is a rare adnexal skin neoplasm with a propensity for metastasis.
  • Cutaneous metastases can present with diverse clinical morphologies, sometimes mimicking benign conditions.

Observation:

  • An 84-year-old female presented with extensive firm skin nodules and severe lymphedema of the left leg.
  • A prior lesion on the ankle, initially diagnosed as actinic keratosis, was re-evaluated histopathologically.

Findings:

  • Metastasizing eccrine porocarcinoma was diagnosed based on circumscribed cutaneous metastases and intraepidermal/intradermal PAS-positive tumor cells.
  • Histopathological re-examination confirmed the malignancy, revealing a 5-year delay from initial misdiagnosis.

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Implications:

  • This case highlights the importance of thorough histopathological review for accurate diagnosis of skin neoplasms.
  • Early and accurate diagnosis is crucial for effective management of eccrine porocarcinoma to potentially alter patient outcomes.
  • The unusual presentation underscores the challenges in diagnosing metastatic adnexal skin cancers.