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Updated: Jun 28, 2026
06:38
Early Detection of Drug-Induced Renal Hemodynamic Dysfunction Using Sonographic Technology in Rats
Published on: March 11, 2016
Drug-induced renal disease
1Northwestern University Medical School, Chicago.
Hospital Practice (Office Ed.)
|April 15, 1993
Summary
Certain medications like aminoglycoside antibiotics, radiocontrast agents, ACE inhibitors, and NSAIDs can harm the kidneys. Prompt identification and management of iatrogenic kidney injury from these drugs are often reversible.
Area of Science:
- Nephrology
- Pharmacology
- Internal Medicine
Background:
- Numerous pharmacologic agents can adversely affect renal function.
- Four drug classes warrant particular clinical attention due to their nephrotoxic potential: aminoglycoside antibiotics, radiocontrast agents, angiotensin-converting enzyme (ACE) inhibitors, and nonsteroidal anti-inflammatory drugs (NSAIDs).
Purpose of the Study:
- To highlight the nephrotoxic potential of commonly used pharmacologic agents.
- To emphasize the importance of recognizing and managing iatrogenic kidney injury.
Main Methods:
- Review of clinical literature on drug-induced kidney injury.
- Identification of key pharmacologic agents and their associated renal complications.
Main Results:
- Common iatrogenic renal complications include acute renal failure, acute interstitial nephritis, and prerenal failure.
- These conditions are frequently associated with aminoglycoside antibiotics, radiocontrast agents, ACE inhibitors, and NSAIDs.
Conclusions:
- Early diagnosis and intervention are crucial for the reversibility of drug-induced kidney injury.
- Clinicians must maintain a high index of suspicion for nephrotoxicity when prescribing these agents.
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