Related Experiment Video

Updated: Jan 9, 2026

Isolation and Analysis of Plasma Lipoproteins by Ultracentrifugation
06:47

Isolation and Analysis of Plasma Lipoproteins by Ultracentrifugation

Published on: January 28, 2021

12.3K

Lipoprotein (a) as an independent risk factor for myocardial infarction in patients with common hypercholesterolaemia

G F Watts1, E M Kearney, N A Taub

  • 1Department of Endocrinology and Chemical Pathology (UMDS), St Thomas's Hospital, London.

Journal of Clinical Pathology
|March 1, 1993
PubMed

Insights

Elevated lipoprotein (a) (Lp(a)) levels significantly increase myocardial infarction (MI) risk in men with hypercholesterolaemia. Routine Lp(a) measurement is recommended for patients at lipid clinics.

Area of Science:

  • Cardiology
  • Lipidology
  • Preventive Medicine

Background:

  • Hypercholesterolaemia is a known risk factor for myocardial infarction (MI).
  • The role of lipoprotein (a) (Lp(a)) as an independent risk factor in this population requires further investigation.

Purpose of the Study:

  • To determine if elevated lipoprotein (a) (Lp(a)) levels are associated with an increased risk of myocardial infarction (MI) in middle-aged men with common hypercholesterolaemia.

Main Methods:

  • A case-control study comparing 15 middle-aged men with hypercholesterolaemia and a history of MI to a control group without MI.
  • Measurement of serum lipids, including low-density lipoprotein (LDL) cholesterol, and lipoprotein (a) (Lp(a)) using immunoturbidity.

Main Results:

  • Patients with MI had significantly higher serum Lp(a) concentrations compared to controls.
  • Lp(a) was identified as the sole significant predictor of MI in logistic regression analysis.
  • An Lp(a) level > 0.57 g/l was associated with an odds ratio of 16.5 for MI.

Conclusions:

  • Serum Lp(a) concentration is a potent and independent risk factor for myocardial infarction in middle-aged men with common hypercholesterolaemia.
  • Routine measurement of Lp(a) is suggested for all patients referred to lipid clinics.
Abstract

More Related Videos

Quantification of Atherosclerosis in Mice06:59

Quantification of Atherosclerosis in Mice

Published on: June 12, 2019

40.0K
Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein07:29

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein

Published on: October 12, 2017

9.7K

Related Concept Videos

Atherosclerosis III: Management01:26

Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
293
Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
795
Coronary Artery Disease IV: Preventive Measures01:26

Coronary Artery Disease IV: Preventive Measures

Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
572
Lipid-Lowering Drugs: Statins and Miscellaneous Agents01:20

Lipid-Lowering Drugs: Statins and Miscellaneous Agents

Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
1.3K
Blood Studies for Cardiovascular System III: Serum Lipid Profile01:25

Blood Studies for Cardiovascular System III: Serum Lipid Profile

Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
534
Cholesterol: Significance and Regulation01:29

Cholesterol: Significance and Regulation

Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
1.2K