Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Systemic sclerosis

M I Perez1, S R Kohn

  • 1Department of Dermatology, Yale University School of Medicine, New Haven, CT 06510.

Journal of the American Academy of Dermatology
|April 1, 1993
PubMed
Summary
This summary is machine-generated.

Systemic sclerosis is a connective tissue disease affecting organs through microvasculature changes and collagen deposition. Diagnosis relies heavily on skin involvement, crucial for patient management.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Burnout is related to executive dysfunction in primary healthcare professionals working in rural areas.

Revista de neurologia·2023
Same author

Topic: Perineal Reconstruction.

Hernia : the journal of hernias and abdominal wall surgery·2015
Same author

A randomized, controlled comparative study of the wrinkle reduction benefits of a cosmetic niacinamide/peptide/retinyl propionate product regimen vs. a prescription 0.02% tretinoin product regimen.

The British journal of dermatology·2010
Same author

Pharmacological interventions for hypertensive emergencies: a Cochrane systematic review.

Journal of human hypertension·2008
Same author

Pharmacological interventions for hypertensive emergencies.

The Cochrane database of systematic reviews·2008
Same author

Intensity dependence of auditory-evoked cortical potentials in fibromyalgia patients: a test of the generalized hypervigilance hypothesis.

The journal of pain·2006
Same journal

Comparative Alopecia Outcomes After Copper and Hormonal Intrauterine Device Placement: A TriNetX Database Retrospective Cohort Study.

Journal of the American Academy of Dermatology·2026
Same journal

Uncovering a Dual Th17/Type 2 Transcriptomic Endotype in Psoriasis.

Journal of the American Academy of Dermatology·2026
Same journal

Dermatologic conditions associated with HIV among US adults across different racial and ethnic groups: A retrospective cohort study using TriNetX.

Journal of the American Academy of Dermatology·2026
Same journal

Ethical Considerations in Same-Day Surgical Treatment of a High-Risk, Poorly Differentiated Squamous Cell Carcinoma.

Journal of the American Academy of Dermatology·2026
Same journal

The Ethics of the Handshake in Dermatology.

Journal of the American Academy of Dermatology·2026
Same journal

Dermatology images: Hidradenitis suppurativa.

Journal of the American Academy of Dermatology·2026
See all related articles

Area of Science:

  • Rheumatology
  • Immunology
  • Dermatology

Background:

  • Systemic sclerosis (SSc) is a multisystem connective tissue disease.
  • It involves microvascular damage, inflammation, and excessive collagen deposition.
  • Cutaneous manifestations are key diagnostic indicators.

Purpose of the Study:

  • To provide a comprehensive review of systemic sclerosis in adults.
  • To cover diagnostic criteria, clinical aspects, and therapeutic strategies.
  • To emphasize the importance of skin involvement in SSc diagnosis and management.

Main Methods:

  • Literature review of systemic sclerosis.
  • Synthesis of information on epidemiology, pathogenesis, and immunobiology.
  • Discussion of diagnostic criteria, clinical subsets, survival, and therapy.

Related Experiment Videos

Main Results:

  • Systemic sclerosis diagnosis is significantly linked to skin manifestations.
  • Understanding cutaneous involvement is vital for effective patient evaluation.
  • The review covers multiple facets of SSc, from genetics to treatment.

Conclusions:

  • Effective management of systemic sclerosis requires a thorough understanding of its diverse clinical features.
  • Cutaneous assessment is paramount in the diagnostic and therapeutic approach to SSc.
  • This review consolidates current knowledge on SSc for clinicians and researchers.