Pigmented spindle cell nevus: a clinicopathologic analysis of ninety-five cases

Area of Science:

• Dermatology
• Pathology
• Oncology

Background:

• Pigmented spindle cell nevus (PSCN) is frequently misdiagnosed as Spitz nevus or malignant melanoma.
• Accurate diagnosis is crucial for appropriate patient management.

Purpose of the Study:

• To analyze clinical and histologic features of 95 Pigmented spindle cell nevus (PSCN) cases.
• To determine the biologic behavior and clinical outcomes of PSCN.

Main Methods:

• Retrospective review of clinical data, follow-up information, and microscopic features.
• Analysis of 95 confirmed cases of Pigmented spindle cell nevus (PSCN).

Main Results:

• Pigmented spindle cell nevus (PSCN) presents as dark brown to black lesions (3-6 mm), common on extremities and back, predominantly in women in their third decade.
• Histologically, PSCN features uniform, spindle-shaped, pigmented melanocytes, distinct from Spitz nevi.
• No local recurrence or metastasis observed in 60% of patients followed for an average of 6 years.

Conclusions:

• Pigmented spindle cell nevus (PSCN) is a unique, acquired, benign melanocytic lesion.
• It should be differentiated from Spitz nevi and malignant melanoma.
• Complete surgical excision is the recommended treatment for PSCN.