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Plasma 3 alpha-androstanediol glucuronide in precocious adrenarche

R Balducci1, G Finocchi, A Mangiantini

  • 1Dipartimento di Sanità Pubblica e Biologia Cellulare, II Università di Roma, Italy.

Journal of Endocrinological Investigation
|February 1, 1993
PubMed
Summary
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Children with precocious adrenarche show elevated levels of 3 alpha-androstanediol glucuronide (3AG), indicating increased skin androgen utilization. This study highlights 3AG as a potential marker for this condition.

Area of Science:

  • Pediatric Endocrinology
  • Androgen Metabolism
  • Dermatology

Background:

  • Precocious pubarche (PP), specifically the benign adrenarcheal form, involves early pubertal development.
  • Understanding androgen levels and their metabolism is crucial for diagnosing and managing PP.

Purpose of the Study:

  • To investigate plasma levels of 3 alpha-androstanediol glucuronide (3AG) in children with precocious adrenarche (PA).
  • To explore the relationship between 3AG and other 5-ene and 4-ene steroids in PA.
  • To determine if 3AG can serve as a marker for skin androgen utilization in PA.

Main Methods:

  • Studied 65 children with PA (aged 3.6-8.2 years) and 15 age-matched controls.
  • Measured plasma levels of androstenedione (A), dehydroepiandrosterone (DHA), DHA sulfate (DHA-S), testosterone (T), dihydrotestosterone (DHT), DHT glucuronide (DHTG), 3 alpha-androstanediol (3Ad), and 3AG.

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Main Results:

  • Children with PA exhibited significantly higher plasma levels of glandular androgens (A, DHA, DHA-S) and peripheral androgens (T, DHT, 3Ad, DHTG) compared to controls.
  • Plasma 3AG levels were significantly elevated in children with PA (1.17 +/- 0.7 nM) versus controls (0.61 +/- 0.04 nM).

Conclusions:

  • Elevated 3AG levels in children with PA suggest increased androgen metabolism within the skin.
  • 3 alpha-androstanediol glucuronide (3AG) may be a valuable marker for assessing skin androgen utilization in precocious adrenarche.