Metastatic prostate cancer simulating sclerosing cholangitis

We report what we believe to be the first case of metastatic prostate cancer presenting as sclerosing cholangitis. In a 71-year-old man with known prostate cancer and cholestatic jaundice, an endoscopic retrograde cholangiopancreatography revealed multifocal strictures of both the intrahepatic and extrahepatic biliary system consistent with sclerosing cholangitis. Review of a liver biopsy and cholecystectomy specimen showed metastases from prostate cancer, which stained positively with prostate-specific antigen. Multiple hepatic metastases from prostate cancer should be included among the conditions that simulate primary sclerosing cholangitis on cholangiography.