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[Normalization of HBA1--a realistic therapeutic goal?]
1Kinderklinik, Städtischen Kliniken Chemnitz.
Insights
Achieving near-normal blood sugar in children with diabetes mellitus is crucial. This study found that 50.1% of pediatric patients reached therapeutic glycemic control, indicated by glycated hemoglobin (HbA1) levels, over one year.
Area of Science:
- Pediatric Endocrinology
- Metabolic Disorders
- Diabetes Mellitus Management
Background:
- Optimal diabetes mellitus therapy in children aims for near-normal glycemia.
- Assessing metabolic control quality relies on sustained normal or near-normal glycated hemoglobin (HbA1) levels.
- Current pediatric diabetology reports indicate this goal is not met by a significant number of patients.
Purpose of the Study:
- To evaluate the achievement of therapeutic glycemic control in children with diabetes mellitus.
- To assess glycated hemoglobin (HbA1) levels in a cohort of pediatric patients over one year.
- To compare findings with existing literature and current therapeutic regimens.
Main Methods:
- HbA1 estimations were performed on 76 children with diabetes mellitus.
- Data were collected over a one-year period.
- Results were analyzed to determine the percentage of patients achieving specific HbA1 ranges.
Main Results:
- 18.4% of children achieved HbA1 values within the normal range (mean + 2 SD).
- 32.9% of children had HbA1 values below mean + 3.5 SD.
- Overall, 50.1% of diabetic children achieved the therapeutic goal of near-normal glycemia (HbA1 below mean + 3.5 SD), suggesting a reduced risk of late vascular complications.
Conclusions:
- Near-normal glycemic control, defined by HbA1 levels below mean + 3.5 SD, was achieved in approximately half of the pediatric diabetes patients studied.
- This level of control may significantly reduce the risk of long-term vascular complications in children with diabetes mellitus.
- Further research and optimization of therapeutic regimens are warranted to improve metabolic control in pediatric diabetology.
Abstract:
Optimal regimen for therapy should lead to near-normal glycaemia in children with diabetes mellitus. Therefore normal or near-normal values of glycated haemoglobin (HbA1) during long periods seem to be very important for the assessment of the quality of metabolic control. However, reports published so far indicate that this goal for paediatric diabetology is currently not achieved in a considerable number of patients. We report on the results of HbA1-estimations in 76 children with diabetes mellitus during a one-year period. We found in 14 (18.4%) children HbA1-values within the normal range (mean + 2 SD) and in 25 (32.9%) children HbA1-values in the range below mean + 3.5 SD. The therapeutic goal near-normal glycaemia with HbA1-values below mean + 3.5 SD and probably no or only a small risk for diabetics to develop late vascular complications could be achieved in 39 (50.1%) diabetic children. Our results are compared with those published in literature and with current therapeutic regimens.