Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Diffusion imaging of experimental allergic encephalomyelitis

A C Heide1, T L Richards, E C Alvord

  • 1Department of Radiology, University of Washington, Seattle 98195.

Magnetic Resonance in Medicine
|April 1, 1993
PubMed
Summary

Diffusion-weighted MRI detects early brain changes in experimental allergic encephalomyelitis (EAE), a multiple sclerosis model, before T2-weighted MRI. This technique reveals subtle pathologies missed by conventional MRI scans.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Reply to comment on: 'Predicting the efficacy of radiotherapy in individual glioblastoma patients in vivo: a mathematical modeling approach'.

Physics in medicine and biology·2016
Same author

Effects of transcutaneous spinal direct current stimulation in idiopathic restless legs patients.

Brain stimulation·2014
Same author

Predicting the efficacy of radiotherapy in individual glioblastoma patients in vivo: a mathematical modeling approach.

Physics in medicine and biology·2010
Same author

Degeneration and necrosis of neurons in eighth cranial nuclei caused by streptomycin.

The American journal of pathology·2010
Same author

Degeneration and necrosis of neurones in eighth cranial nuclei caused by streptomycin.

Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)·2010
Same author

Allergy in the nervous system a review of the literature.

The American journal of medicine·2010

Area of Science:

  • Neuroimaging
  • Experimental Neurology
  • Magnetic Resonance Imaging

Background:

  • Multiple sclerosis is a demyelinating disease of the central nervous system.
  • Experimental allergic encephalomyelitis (EAE) is a widely used animal model to study multiple sclerosis pathogenesis.
  • Conventional MRI sequences like T2-weighted imaging are crucial for monitoring disease progression.

Purpose of the Study:

  • To compare the sensitivity of diffusion-weighted magnetic resonance imaging (dMRI) versus T2-weighted MRI (T2w-MRI) in detecting pathological changes in the brain.
  • To investigate the potential of dMRI to identify early or subtle abnormalities in an animal model of multiple sclerosis.

Main Methods:

  • Longitudinal diffusion-weighted MRI and T2-weighted MRI scans were performed on five Macaca fascicularis monkeys with experimentally induced allergic encephalomyelitis (EAE).

Related Experiment Videos

  • Image analysis focused on detecting sequential changes in specific brain regions, particularly the internal capsule, known for its highly directional myelinated fibers.

    • Main Results:

    • Diffusion-weighted imaging identified pathological changes in the internal capsule on and preceding the day these changes were visible on T2-weighted MRI.
    • dMRI detected abnormalities in brain areas that did not exhibit T2-weighted signal changes, indicating higher sensitivity.
    • These findings suggest dMRI is sensitive to early or sub-visual pathological conditions.

    Conclusions:

    • Diffusion-weighted MRI demonstrates superior sensitivity in detecting early pathological changes in the EAE model compared to conventional T2-weighted MRI.
    • dMRI may serve as a valuable tool for earlier diagnosis and monitoring of neuroinflammatory conditions like multiple sclerosis.
    • The study highlights the potential of dMRI to reveal subtle brain pathologies not discernible by standard MRI techniques.