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[Allergic inflammatory markers in upper respiratory allergies]

L Nagy1, M Orosz, Z Süttö

  • 1Pulmonológiai Klinika, Semmelweis Orvostudományi Egyetem, Budapest.

Orvosi Hetilap
|April 4, 1993
PubMed
Summary

In allergy patients, eosinophil cationic protein levels were elevated, indicating eosinophil activation. Mast cell activation, measured by serum tryptase, showed no significant changes in upper respiratory tract allergy.

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Area of Science:

  • Immunology
  • Allergy Research
  • Respiratory Medicine

Context:

  • Investigating inflammatory mediators in symptomatic upper respiratory tract allergy patients.
  • Assessing mast cell and eosinophil activation as key players in allergic responses.

Purpose:

  • To determine the levels of serum tryptase and serum eosinophil cationic protein in patients with upper respiratory tract allergy.
  • To correlate these inflammatory markers with symptom severity and peripheral blood eosinophil counts.

Summary:

  • Serum tryptase levels, indicating mast cell activation, were unchanged in symptomatic allergy patients.
  • Serum eosinophil cationic protein levels, indicating eosinophil activation, were significantly elevated compared to healthy controls.
  • No correlation was found between these markers and symptom severity or peripheral eosinophil counts.

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Impact:

  • Highlights the significant role of eosinophil activation in upper respiratory tract allergy.
  • Suggests eosinophil cationic protein as a potential biomarker for allergic inflammation.
  • Provides insights into the complex mechanisms of allergic responses, including the role of Th2-helper lymphocytes.