Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Bronchial hyperreactivity to distilled water]

M Studnicka1, T Frischer, M Neumann

  • 1Erste Abteilung am Pulmologischen Zentrum, Wien.

Pneumologie (Stuttgart, Germany)
|February 1, 1993
PubMed
Summary

Distilled water inhalation challenges identified a strong association with asthma in children. This safe and simple method may serve as an alternative to methacholine provocation testing for asthma diagnosis.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Performance of the ATLAS track reconstruction algorithms in dense environments in LHC Run 2.

The European physical journal. C, Particles and fields·2017
Same author

Search for the Dimuon Decay of the Higgs Boson in pp Collisions at sqrt[s]=13  TeV with the ATLAS Detector.

Physical review letters·2017
Same author

Performance of the ATLAS trigger system in 2015.

The European physical journal. C, Particles and fields·2017
Same author

Reconstruction of primary vertices at the ATLAS experiment in Run 1 proton-proton collisions at the LHC.

The European physical journal. C, Particles and fields·2017
Same author

Jet reconstruction and performance using particle flow with the ATLAS Detector.

The European physical journal. C, Particles and fields·2017
Same author

Measurements of electroweak [Formula: see text] production and constraints on anomalous gauge couplings with the ATLAS detector.

The European physical journal. C, Particles and fields·2017

Area of Science:

  • Pediatric Pulmonology
  • Clinical Allergy and Immunology
  • Respiratory Medicine

Context:

  • Asthma diagnosis in children often relies on provocative testing.
  • Methacholine provocation testing is a standard but can have limitations.
  • Alternative, safer provocation methods are needed for pediatric populations.

Purpose:

  • To evaluate the efficacy and safety of distilled water aerosol inhalation as a provocative challenge test for asthma in children.
  • To compare the results of distilled water challenge with asthma diagnosis and other relevant symptoms.

Summary:

  • An epidemiological study involved 446 children undergoing a 10-minute tidal inhalation of ultrasonically nebulized distilled water.
  • Children with a clinical asthma diagnosis showed significantly higher odds (OR=9.1) of a positive challenge test compared to non-asthmatics.
  • Cough, nocturnal cough, and atopy (via prick testing) were significantly associated with positive distilled water challenges.

Impact:

  • Distilled water challenge presents a simple, safe, and potentially effective alternative to methacholine provocation for diagnosing asthma in children.
  • This method offers a pathophysiologically relevant stimulus with minimal side effects.
  • Findings support the use of distilled water inhalation in epidemiological studies and potentially in clinical settings for asthma assessment.

Related Experiment Videos